miRKO Knockout Pipeline Database

Welcome to the Keck Knock-Out Mouse pipeline page. This set of pages was developed by our team to internally track project workflow, and we have made it live in hopes that you will find some helpful data. Jackson Labs will create more formalized pages, and hopefully soon we will add a link to their pages.

Please click on the name of a microRNA below to see our progress towards generating a conditional knock-out mouse for that microRNA. Clicking on the images will reveal some of the underlying data. Also, click on the "microRNA" or "Status" column headings to sort the table by the values in those fields.

microRNAsort icon Vector Map family 5'-arm 3'-arm chimeras lacZ Status
mir-122 mir-122 Work Begun on Construct
miR-10b mir-10 Completed
miR-10a mir-10 Chimeras have been Produced
miR-107 mir-103 Construct Created and QCd
miR-103-2 mir-103 No Data
miR-103-1 mir-103 No Data
miR-101b mir-101 Construct Created and QCd
miR-101a mir-101 Work Begun on Construct
miR-100 mir-99 ES Cells have been Targeted
mir-1.2 mir-1 Work Begun on Construct
mir-1.1 mir-1 Transgene was Transmitted through Germli
miR-1-1/ mir-133a-2
mir-1
mir-133
No Data
let-7i let-7 Construct Created and QCd
let-7g let-7 Construct Created and QCd
let-7f-2/ miR-98 let-7 Construct Created and QCd
let-7e let-7 ES Cells have been Targeted
Let-7e let-7 Construct Created and QCd
let-7d/ let-7f-1/ let-7a-1 let-7 Completed
let-7c-2/ let-7b let-7 Transgene was Transmitted through Germli
let-7a-2 let-7 ES Cells have been Targeted